My experience with Prozac

Prozac, or Fluoxetine, was the first antidepressant that I took for depression. I started taking it in late March of 2018 while I was hospitalized for what a psychiatrist called a severe depressive episode associated with Major Depressive Disorder.

I was prescribed 20mg of Prozac, and I was instructed to take it at the same time (or as close as possible) every day. I read about how Prozac works within the body and the possible side effects so that I would be aware of both positive and negative effects.

Potential benefits of Prozac

Prozac is used to treat depression, panic attacks, obsessive compulsive disorder, bulimia, and a severe form of premenstrual syndrome. It may help improve your mood, energy levels, appetite, and disturbances in sleep. It may decrease anxiety, the frequency of panic attacks, and unwanted thoughts.

It has also been known to help the urge to perform repeated tasks that are associated with obsessive compulsive disorder, as well as some premenstrual symptoms such as irritability, depression, and increased appetite. It may also decrease binging and purging behaviors that are associated with bulimia.

Potential side effects of Prozac

Prozac has been known to cause a number of side effects. Possible side effects include but are not limited to drowsiness, tiredness, yawning, loss of appetite, headaches, trouble sleeping, nausea, dizziness, sweating, and anxiety. These are the most common, and most of these symptoms should subside after two or three weeks of taking the medication. If they don’t or if any of them become too much to handle, just get in touch with your doctor.

More severe side effects include unusual or drastic mood changes, frequent headaches or migraines, easy bruising or bleeding, muscle weakness or spasms, shakiness or tremors, unusual weight loss, decreased interest in sex or sexual ability, or thoughts of suicide. These symptoms are unlikely, but still possible.

Rare but very serious side effects include unusual agitation or restlessness, fast or irregular heartbeat, eye pain or swelling or redness, widened pupils, changes in vision, unexplained fever, bloody or black stools, vomit that looks like coffee grounds, severe nausea or vomiting or diarrhea, changes in urine or other signs of potential kidney problems, hallucinations, loss of coordination, severe dizziness, fainting, or seizures.

A severe allergic reaction is rare but possible. An allergic reaction could be a rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing.

Males may have a painful or prolonged erection lasting four or more hours. If this occurs, you should stop taking Prozac and seek immediate medical attention. This is a rare but serious side effect. Permanent problems could occur if you do not seek medical help right away.

It is also worth noting that Prozac may affect blood sugar levels. If you have diabetes, be sure to monitor your blood sugar regularly and share any abnormalities with your doctor. He or she may choose to adjust your medication, suggest dietary changes, or recommend an exercise routine.

This medication may increase serotonin and could rarely cause a very serious condition called serotonin syndrome, otherwise known as serotonin toxicity. The risk for experiencing this particular side effect increases if you are also taking other drugs that increase serotonin. Be sure to give your doctor a complete list of all of the medications you are currently taking.

If you experience any of the above symptoms, you need to either contact your doctor or seek immediate medical attention depending on severity.

I used WebMD to help me list most of the possible side effects that you may experience while taking Prozac. It isn’t a complete list, so please be sure that you note any effects that you experience while taking Prozac if you didn’t experience said effects before taking Prozac.

I am not a medical professional, so please contact your doctor or a pharmacist if you have any questions about possible side effects or drug interactions.

My first month taking Prozac

Like most people, I didn’t experience any changes or side effects for the first week or two. My psychiatrist let me know that it was normal to not notice any significant changes, or any at all, until after a few weeks. Some people don’t notice any differences until after a month has passed.

During the third or fourth week, I started to notice that I was having frequent headaches.

My second month taking Prozac

During the second month, my headaches were so frequent that I was having multiple ones every single day. That alone was a depressive experience. As far as my actual depressive symptoms, I didn’t notice any changes with my mood.

At that point in time, I hadn’t yet seen a psychiatrist since I was discharged from the hospital. I scheduled an appointment with one, but they weren’t able to get me in for a couple of months since I was a new patient to their office. I scheduled an appointment with my nurse practitioner in the meantime, as the psychiatrist I saw in the hospital suggested, so that I could get my prescription refilled.

I let my nurse practitioner know what was going on, including the frequent headaches that I was experiencing. She decided to not increase my dose since I had an appointment scheduled with a psychiatrist. She didn’t want to change anything with my medication in case my psychiatrist ended up switching the medication I was taking, which would make an increase in Prozac rather pointless.

I continued taking 20mg of Prozac through the second month, but I got so tired of the headaches that I decided to quit taking it without weaning myself off of it, despite being told not to by the psychiatrist I saw in the hospital.

The headaches were absolutely miserable. There were days where they were almost migraine-level, and the only thing that would help was sitting or laying in a quiet room with the lights off. Most of the time, I didn’t take any over-the-counter medication for them because I knew it would be an every day thing, which isn’t advisable either.

After I quit taking Prozac, it was such a relief. I still had headaches a couple of days after not taking it, but after that, I was headache-free.

As I waited for my psychiatrist appointment in early July of 2018, my husband and I started to see a marriage counselor to help us with communication. He got a brief history from both of us, including my experience with Prozac. He advised me to start taking it again, despite the headaches. Reluctantly, I did just that.

The headaches came back, of course. Thankfully, June flew by rather quickly for me, which meant that my appointment with my psychiatrist was soon. I was eager to tell her about my headaches.

My appointment with a psychiatrist

After speaking with my psychiatrist, she decided to take me off the Prozac since I didn’t have headaches before taking it, and they subsided after I stopped taking it. She prescribed Zoloft. She informed me of the possible side effects and to let her know if I experience any negative symptoms, such as the headaches I experienced on Prozac.

She told me that Zoloft is a close relative of Prozac and, if I also have negative side effects with Zoloft, it’s possible that that family of antidepressants is not for me.

I’m still in the early stages of Zoloft so I don’t have much to report, but I’ll be writing a post about my experiences with it after more time.

Have you ever taken Prozac? If so, does or did it work for you? If you were recently prescribed Prozac, feel free to comment and let me know if you have any questions or comments, and if you’ve experienced any improvements or side effects. I’d love to hear from you!


My name is Nicole, and I’m very happy that you decided to stop by and visit my blog! I write about mental health, and I post the occasional product review. I’m most passionate about writing, mental health advocacy, and gaming. My husband and I live in the South with our five tabby cats and two parakeets. If you ever want to connect with me, please don’t hesitate to visit my Contact page.

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  1. August 1, 2018 / 12:55 PM

    I took Prozac for almost a year, as I was misdiagnosed with ADHD and Major Depression. However I have bipolar disorder. Taking antidepressants tends to make mania worse, and that’s exactly what happened. When I got off if it my mania symptoms became less frequent and intense and I was placed on the right medication for my diagnosis. I luckily didn’t have the headaches that you did.

    • Nicole
      August 1, 2018 / 2:55 PM

      I heard that it can cause manic symptoms in those with Bipolar. It’s crazy what effects that meds can have. The headaches were miserable, but after researching all of the symptoms, I could’ve had a lot worse. I’m glad that you were able to get on the right medication, though!

  2. Selina
    August 1, 2018 / 5:36 PM

    Thank you for your posts. I stumbled on with all our mental health awareness. I want to say I can so relate to so much of happy 1 minuet sad or angry the next for no obvious reason. I started tracking my changes in mood & isolated to monthly hormonal changes. Was doing therapy them and dr wantedme onthe pill and antidepressants. Suicide thoughts plaged me a week before my period and depression of this cycle nearly destroyed me. After finding a qualified naturopath dr and examined blood we took an approach that helped. I found the pill made me worse and was angry at the medical community to so quickly offer a pill to fix us rather than digging to find the problem. Me too much estrogen got that in check and life became better for my marriage and my 4 kids. Keep up bringing awareness.

    • Nicole
      August 1, 2018 / 9:24 PM

      I’m so glad that you came across my blog! I love meeting other people who care about spreading awareness, too. I know exactly what you mean with the mood switching. Most of the time, mine is caused by situational things, like if something happens and disrupts my plans or if someone does or says something that triggers me. The suicidal thoughts are definitely the worst, though. I’m glad that you were able to find an approach that worked for you. I’m eagerly awaiting the day where I find the right medication and dosage for me.

  3. August 3, 2018 / 5:06 PM

    Prozac actually worked better for me than zoloft (which made me gassy/gassier than usual). Good luck on finding the right meds! It can be tough to find the right combo, so here’s hoping Zoloft works for you.

    • Nicole
      August 4, 2018 / 1:48 AM

      Thank you! Yeah, it sucks that it’s such a huge trial and error, but I’m just trying to hang in there. I have to find the right combination eventually. 🙂

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